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Intravenous Alteplase for Stroke with Unknown Time of Onset Guided by Advanced Imaging:Systematic Review and Meta-Analysis of Individual Patient Data
Lancet 396:1574-1585, Thomalla,G.,et al, 2020
See this aricle in Pubmed

Article Abstract
In patients who have had a stroke with unknown time of onset with DWI-FLAIR or perfusion mismatch, intravenous alteplase resulted in better functional outcome at 90 days than placebo or standard care. A net benefit was observed for all functional outcomes despite an increased risk of symptomatic intracranial haemorrhage. Although there were more deaths with alteplase than placebo, there were fewer cases of severe disability or death.
 
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CAT scan,perfusion
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cerebrovascular accident,awakening with
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cerebrovascular accident,time of onset
cerebrovascular accident,unknown time of onset
efficacy
MRI,abnormal
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MRI,mismatch between perfusion/diffusion
safety
tissue plasminogen activator,intravenous
treatment of neurologic disorder

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