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In patients who have had a stroke with unknown time of onset with DWI-FLAIR or perfusion mismatch, intravenous alteplase resulted in better functional outcome at 90 days than placebo or standard care. A net benefit was observed for all functional outcomes despite an increased risk of symptomatic intracranial haemorrhage. Although there were more deaths with alteplase than placebo, there were fewer cases of severe disability or death. |
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CAT scan,perfusion cerebrovascular accident cerebrovascular accident,awakening with cerebrovascular accident,thrombolytic agents in treatment cerebrovascular accident,time of onset cerebrovascular accident,unknown time of onset efficacy MRI,abnormal MRI,mismatch between DWI/FLAIR MRI,mismatch between perfusion/diffusion safety tissue plasminogen activator,intravenous treatment of neurologic disorder
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