|
|
|
|
|
Click Here to return To Results
|
|
|
|
The Hemostasis and Thrombosis Laboratory at the Oregon Health Sciences University identified 80 patients with significantly elevated anticardiolipin antibody(ACLA)levels.We reviewed all of their available medical records and found that 25 of these patients had associated neurological symptoms or disorders.These symptoms and disorders could be grouped into four distinct clinical patterns comprising encephalopathy, multiple cerebral infarctions,migraine-like headaches,and visual abnormalities including amaurosis fugax and ischemic optic neuropathy. Cerebral ischemia best explained these neurological dysfunctions.There was no correlation between the presence or absence of neurological disease and ACLA levels,but ACLA levels were higher in patients with encephalopathy than in others with neurological involvement(p,0.05).How neurological dysfunction and the presence of these antiphospholipid antibodies are related remains to be clarified.Nevertheless,in patients with unexplained cerebral ischemia,establishing the presence of ACLA may have prognostic and therapeutic importance.In particular,acute immunosuppressive therapy and plasmapheresis may be useful in patients with acute ischemic encephalopathy. |
|
(click to filter results - removes previous filter)
amaurosis fugax
anticardiolipin antibodies
antiphospholipid antibodies
CAT scan
CAT scan,abnormal
cerebral ischemia
cerebrovascular accident
cerebrovascular accident,multiple
cerebrovascular disease,risk factors in
encephalopathy
false positive VDRL
headache
lupus anticoagulant
migraine
optic neuropathy
optic neuropathy,ischemic
prothrombin time,prolonged
retinal infarction
thrombocytopenia
|
Click Here to return To Results
|
|