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Nifedipine in the Prophylaxis of Classic Migraine:A Crossover, Double-Masked, Placebo-Controlled Study of Headache Neurol 39:284-286, McArthur,J.C.,et al, 1989 See this aricle in Pubmed Article Abstract Twenty-four patients with classic migraine attacks were treated with either nifedipine or placebo for up to 12 weeks.No significant differences were observed between the nifedipine(2.1 plus/minus 0.2)and placebo(2.3 plus/minus 0.2)treatment groups in the monthly frequency of headaches. However,the incidence of side effects was significantly greater(p<0.001)in the nifedipine(54%of patients)than in the placebo(8%of patients)treatment groups.

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