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A selective subtotal cerebellar neuronal degeneration was found in a patient who died 4 1/2 months after suffering neuroleptic malignant syndrome(NMS),a rare,potentially fatal disorder associated with neuroleptic medications.It is suggested that the cerebellar neuronal degeneration in this case was due to hyperpyrexia,a cardinal clinical feature of NMS.Similar pathologic findings appear not to have been previously reported in NMS but have been described in heat-induced central nervous system(CNS)injury.The findings imply that a cerebellar syndrome might be encountered in patients who survive NMS complicated by a particularly high febrile course. |
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