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We transplanted autologous adrenal medullary cells to the caudate nucleus in 3 patients with progressive supranuclear palsy,using the method Madrazo has employed for neural transplantation in Parkinson's disease.Major and minor complications occurred post-operatively from which the patients recovered.One patient had a marked improvement in his postural stability and a decreased incidence of falling.This change was evident at 1 month after surgery and has remained for the 6 months of follow-up.Postural reflexes were not altered in the other 2 patients.There was no change in extraocular movements,speech,or the rigid-bradykinetic features of parkinsonism in any patient.Adrenal medullary transplantation has only limited efficacy in progressive supranuclear palsy. |
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