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Dissociation of AIDS-Related Vacuolar Myelopathy and Productive HIV-1 Infection of the Spinal Cord Neurol 39:892-896, Rosenblum,M.,et al, 1989 See this aricle in Pubmed Article Abstract Although merging clinically within the spectrum of the AIDS dementia complex,vacuolar myelopathy is a pathologically distinct entity detected in up to 30%of autopsied patients succumbing to the late complications of human immunodeficiency virus type 1(HIV-1)infection.Using immunohistochemistry and in situ hybridization to detect an HIV-1 core protein and viral mRNA,respectively,in tissue sections,and culture isolation to assess infectious virus in tissue homogenates,we found that vacuolar myelopathy was independent of productive HIV-1 infection of the spinal cord and brain.These results indicate that AIDS-associated vacuolar myelopathy is either not related directly to spinal cord HIV-1 infection or involves nonproductive infection and pathobiological processes distinct from those responsible for the multinucleated-cell inflammatory infiltrates that serve as histopathologic markers of productive CNS HIV-1 infection.

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(click to filter results - removes previous filter) acquired immunodeficiency syndrome acquired immunodeficiency syndrome myelopathy human immunodeficiency virus type 1 myelopathy myelopathy,vacuolar neuropathology spinal cord spinal cord,lesion of spinal cord,pathologic exam of

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