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Increased Replication of HTLV-I in HTLV-I-Associated Myelopathy Ann Neurol 26:331-335, Yoshida,M.,et al, 1989 See this aricle in Pubmed Article Abstract To estimate the replication of the human T-cell leukemia virus type I (HTLV-I)in patients with HTLV-I-associated myelopathy(HAM),or tropical spastic paraparesis(TSP),HTLV-I DNA integrated into lymphocyte genomes was analyzed by Southern blot hybridization.HTLV-I DNA was detected in 125 (82%)of 153 patients and most showed random integration.This incidence was much higher than the 29%found in asymptomatic carriers.Therefore,HAM/TSP development is associated with a high level of HTLV-I replication.In addition,lymphocytes from 3 patients with HAM/TSP showed monoclonal integration of HTLV-I DNA,indicating adult T-cell leukemia.

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(click to filter results - removes previous filter) human T-lymphotropic virus type I(HTLV-I) leukemia myelopathy myelopathy,chronic progressive paraparesis paraparesis,spastic,tropical viral infection

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