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Molecular Biology of Duchenne and Becker's Muscular Dystrophy:Clinical Applications
Ann Neurol 26:189-194, Gutmann,D.H.&Fischbeck,K.H., 1989
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Article Abstract
Recent advances in molecular genetics have led to the isolation of the gene defective in patients with Duchenne and Becker's muscular dystrophy and the characterization of its protein product,dystrophin.In this communication,the developments culminating in the identification of the Duchenne muscular dystrophy locus are reviewed.The practical applications of this research and pitfalls that limit prenatal diagnosis and carrier detection are discussed.
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amniocentesis
DNA probes
dystrophin
gene
genetic counselling
genetic diagnosis,prenatal
molecular genetics
muscular dystrophy
muscular dystrophy,Becker
muscular dystrophy,Duchenne
muscular dystrophy,Duchenne,carrier
prenatal diagnosis by amniocentesis
recombinant DNA
review article
RFLPs
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