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We successfully and serially transmitted to outbred and inbred strains of hamsters the brain tissue of a 2 1/2-year-old girl with a chronic progressive encephalopathy(Alpers'disease)characterized postmortem as a spongiform encephalopathy.In all hamster strains we produced a spongiform encephalopathy.The light and ultrastructural changes in the brain of hamsters,as well as the clinical signs of experimental disease,are identical to those obtained in transmission experiments of human Creutzfeldt-Jakob disease(CJD).CJD infection may be more widespread than previously recognized and can be manifested in infancy. |
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