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Gabapentin Does Not Interact with a Contraceptive Regimen of Norethindrone Acetate and Ethinyl Estradiol
Neurol 50:1146-1148, Eldon,M.A.,et al, 1998
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Article Abstract
Anticonvulsants that induce hepatic metabolism increase clearance of oral contraceptive hormones and thereby cause contraceptive failure.Gabapentin is not metabolized in humans and has little liability for causing metabolic-based drug-drug interactions.In healthy women receiving 2.5 mg norethindrone acetate and 50 ug ethinyl estradiol daily for three consecutive menstrual cycles,concurrent gabapentin administration did not alter the steady-state pharmacokinetics of either hormone.Thus,gabapentin is unlikely to cause contraceptive failure.
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anticonvulsants,untoward effects of
drug interactions
oral contraceptives

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