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Clinical Presentation and Pharmacological Therapy in Corticobasal Degeneration
Arch Neurol 55:957-961, Kompoliti,K.,et al, 1998
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Article Abstract
A total of 147 case patients were reviewed,7 were autopsy proven. Parkisonian features were present in all,other movement disorder in 89%, and higher cortical dysfunction in 93%.The most common parkinsonian sign was rigidity,followed by bradykinesia,gait disorder,and tremor.Other movement disorders were dystonia in 71%and myoclonus in 55%.Higher cortical dysfunction included dyspraxia,alien limb,cortical sensory loss, and dementia.Ninety-two percent of the case patients received dopaminergic drugs which resulted in a beneficial effect for 24%.Parkinsonian signs were the elements of improving the most and levodopa was the most effect drug.Benzodiazepines,primarily clonazepam were administered to 47 case patient,which resulted in improvement in myoclonus in 23%and dystonia in 9%.The most frequent disability adverse effects of drug trials in these case patients were somnolence,gastrointestinal complaints,confusion, dizziness,hallucinations and dry mouth.Pharmacological intervention was largely ineffective in the management of corticobasal degeneration and new treatments are needed for ameliorating the symptoms of this syndromes.
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alien hand syndrome
cortical-basal ganglionic degeneration
gait disorder
neurologic signs
neurologic symptoms
Parkinson disease
Parkinsonism syndrome
review article
sensory loss,cortical
treatment of neurologic disorder

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