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Amyloidosis Causing A Progressive Myopathy
Muscle & Nerve 18:1016-1018995., Nadkarni,N.,et al, 1995
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Article Abstract
A 62-year-old woman developed profound weakness secondary to a progressive myopathy associated with primary systemic amyloidosis.The characteristic apple-green birefringent amyloid deposits were demonstrated surrounding individual muscle fibers in Congo red stained sections.Electron microscopy demonstrated amyloid filaments in close apposition to muscle fibers exhibiting excessive corrugations of the sarcolemmal membrane.The pathological features of progressive amyloid myopathy associated with primary systemic amyloidosis are distinct from the intracellular amyloid deposits characteristic of sporadic inclusion body myositis and inherited inclusion body myopathy.
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