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Central Nervous System Involvement in the Eosinophilia-Myalagia Syndrome
Arch Neurol 49:1082-1085, Lynn,J.,et al, 1992
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Article Abstract
A patient with eosinophilia-myalgia syndrome developed progressive central nervous system involvement that did not improve despite discontinuation lf L-tryptophan therapy.Neurologic impairment was manifested initially by spastic monoparesis,which was improved by teratment with methylprednisolone and hydroxyurea.Recurrence of weakness was accompanied by gait ataxia,dysphagia,and complaints of a gradual decline in memory and concentration.Neuropsychgological testing identified a broad pattern of cognitive deficits suggestive of a subcortical dementia,and magnetic resonance imaging demonstrated multiple high-signal lesions in the white matter.Cognitive deficits appear to be underrecognized in patients with the eosinophilia-myalgia syndrome.The response of our patient's initial symptoms to corticosteroid therapy suggests a possible role for autoimmune mechanisms in the pathogenesis of central vernous system involvement in the eosinophilia-myalgia syndrome.neuropsychological evaluation should be performed in patients with cognitive complaints to delineate the full spectrum of central nervous system impairment associated with the eosinophilia-myalgia syndrome.
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ataxic gait
eosinophilia-myalgia syndrome
intellectual deficit
memory,impairment of
psychological testing
psychological testing,neurologic problems

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