Intravenous Alteplase for Stroke with Unknown Time of Onset Guided by Advanced Imaging:Systematic Review and Meta-Analysis of Individual Patient Data
Lancet 396:1574-1585, Thomalla,G.,et al, 2020
Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke
NEJM 380:1795-1803,1865, Ma, H.,et al, 2019
Extending Thrombolysis to 4.5-9 h and Wake-Up Stroke Using Perfusion Imaging: A Systematic Review and Meta-Analysis of Individual Patient Data
Lancet 394:139-147,97, Campbell, B.C.V.,et al, 2019
Hyperintense Vessels on FLAIR: Hemodynamic Correlates and Response to Thrombolysis
AJNR 36:1426-1430, Kufner, A.,et al, 2015
Treatment Concepts for Wake-Up Stroke and Stroke with Unknown Time of Symptom Onset
Stroke 46:2707-2713, Thomalla, G. & Gerloff, C., 2015
Endovascular Treatment for Acute Ischemic Stroke-Still Unproven
NEJM 368:952-955, Chimowitz,M., 2013
Advanced Brain Imaging Studies Should Be Performed in Patients With Suspected Stroke Presenting Within 4.5 Hours of Symptom Onset
Stroke 42-2666-2667,2670, Parsons, M.W., 2011
Advanced Brain Imaging Studies Should Not Be Performed in Patients With Suspected Stroke Presenting Within 4.5 Hours of Symptom Onset
Stroke 42:2668-2669,2670, Lyden, P.D., 2011
Cost-Effectiveness of Patient Selection Using Penumbral-Based MRI for Intravenous Thrombolysis
Stroke 40:1710-1720, Earnshaw,S.R.,et al, 2009
Comparison of CT Perfusion and Angiography and MRI in Selecting Stroke Patients for Acute Treatment
Neurol 68:694-697, Wintermark,M.,et al, 2007
Evaluation of the Clinical-Diffusion and Perfusion-Diffusion Mismatch Models in DEFUSE
Stroke 38:1826-1830,1718, Lansberg,M.G.,et al, 2007
Is Penumbral Imaging Useful for Extending the Treatment Window for Intravenous Tissue Plasminogen Activator?
Ann Neurol 60:499-501, Fisher,M., 2006
Perfusion-Weighted Imaging/Diffusion-Weighted Imaging Mismatch on MRI Can Now be Used to Select Patients for Recombinant Tissue Plasminogen Activator Beyond 3 Hours
Stroke 36:1099-1100, 1100, Zivin,J.A., 2005
Perfusion-Weighted Imaging/Diffusion-Weighted Imaging Mismatch on MRI Can Now Be Used to Select Patients for Recombinant Tissue Plasminogen Activator Beyond 3 Hours
Stroke 36:1098-1099,1100, Schellinger,P.D. &Fiebach,J.B., 2005
The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): A Phase II MRI-Based 9-Hour Window Acute Stroke Thrombolysis Trial With Intravenous Desmoteplase
Stroke 36:66-73, Hacke,W.,et al, 2005
Are There Time-Dependent Differences in Diffusion and Perfusion Within the First 6 Hours After Stroke Onset?
Stroke 35:2099, Fiehler,J.,et al, 2004
Acute Intravenou-Intra-Arterial Revascularization Therapy for Severe Ischemic Stroke
Stroke 33:279-282, Hill,M.D.,et al, 2002
Thrombolysis in Stroke Beyond Three Hours: Targeting Patients With Diffusion and Perfusion MRI
Ann Neurol 51:11-13,28, Warach,S., 2002
Thrombolytic Therapy Within 3 to 6 Hours After Onset of Ischemic Stroke
Stroke 33:1437-1441, Ringleb,P.A.,et al, 2002
Intravenous Thrombolysis Use in the Late Time Window Before Interhospital Transfer for Thrombectomy
JAMA Neurol 83:60-67, Seners,P.,et al, 2026
Tenecteplase for Acute Non-Large Vessel Occlusion 4.5 to 24 Hours After IschemicStroke, The OPTION Randomized Clinical Trial
JAMA doi:10.1001/JAMA.2026.0210, Ma,G.,et al, 2026
Safety and Outcomes of Dibigatran Reversal with Idarucizumab Before IV Thrombolysis in Patients with Acute Ischemic Stroke
Neurol 106:e218012, Saflund,M.,et al, 2026
Efficacy and Safety of IV Thrombolysis for Acute Ischemic Stroke Patients with Moyamoya Disease
Neurol 104:e210243, Chen,H.,et al, 2025
Endovascular Thrombectomy for Extracranial Internal Carotid Artery Occlusions with Large Ischemic Strokes
Neurol 104:e210269, Ortega-Gutierrez,S.,et al, 2025
Endovascular Therapy for Patients with Low NIHSS Scores and Large Vessel Occlusion in the 6- to 24-Hour Window
Neurol 104:e213442, Marto,J.P.,et al, 2025
Endovascular Treatment of Stroke Due to Medium-Vessel Occlusion
NEJM 392:1385-1395,1440, Goyal,lM.,et al, 2025
Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels
NEJM 392:1374-1384,1440, Psychogios,M.,et al, 2025
Intravenous Tenecteplase before Thrombectomy in Stroke
NEJM 393:139-150, Qiu,Z.,et al, 2025
Endovascular Treatment in Acute Ischemic Stroke Due to Occlusion of Medium or Distal Vessels
Neurol 105:e214015, Palaiodimou,L.,et al, 2025
Early Tirofiban Infusion after Intravenous Thrombolysis for Stroke
NEJM 393:1191-1201, Tao,C.,et al, 2025
Intravenous Thrombolysis Use Before Inter-Facility Transfer for Thrombectomy:Association with Efficacy and Safety Outcomes
Ann Neurol 98:871-880, Seners,P.,et al, 2025
Upbeat Nystagmus From Dorsolateral Pontine Hemorrhagic Transformation
Neurol 106:e214467, Chen,H. & Li, J., 2025
Tenecteplase for Stroke - Opening the Window?
NEJM 390:760-761, Leifer,D.,, 2024
Treatment and Outcomes of Cervical Artery Dissection in Adults:A Scientific Statement From the American Heart Association
Stroke 55:e91-e106, YaghikS.,et al, 2024
Eye Toward Stroke Prevention:Central Retinal Artery Occlusion and Tandem Internal Carotid Artery Occlusion
Stroke 55:e165-e168, Cheronis,C.,et al, 2024
Tenecteplase Versus Standard of Care for Minor Ischaemic Stroke with Proven Occlusion (TEMPO-2): A Randomised, Open Label, Phase 3 Superiority Trial
Lancet 403:2597-2605, Coutts,S.B.,et al, 2024
Small Step or Giant Leap? Expanding the Acute Stroke Thrombolysis Window to 24 Hour
NEJM 391:273-275, Lee,V.H., 2024
Diffusion-Weighted Imaging Fluid-Attenuated Inversion Recovery Mismatch on Portable, Low-Field Magnetic Resonance Imaging Amont Acute Stroke Patients
Ann Neurol 96:321-331, Sorby-Adams,A.,et al, 2024
Intravenous Thrombolysis in Patients with Cervical Artery Dissection
Neurol 103:e209843, Shu,L.,et al, 2024
Thrombolysis After Dabigatran Reversal for Acute Ischemic Stroke
Neurol 103:e209862, Theodorou,A.,et al, 2024
Effect of IV Thrombolysis With Alteplase in Patients with Vessel Occlusion in the WAKE-UP Trial
Neurol 104:e209871, Galinovic,I.,et al, 2024
Lecanemab in Early Alzheimers Disease
NEJM 388:9-21,80, van Dyck,A.H.,et al, 2023
Intravenous Thrombolysis in Patients with Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants
JAMA Neurol 80:233-243, 231, Meinel,T.R.,et al, 2023
Endovascular Therapy or Medical Management Alone for Isolated Posterior Cerebral Artery Occlusion: A Multicenter Study
Stroke 54:928-937, Sabben,C.,et al, 2023
Magnetic Resonance Imaging or Computed Tomography for Suspected Acute Stroke: Association of Admission Image Modality with Acute Recanalization Therapies, Workflow Metrics, and Outcomes
Ann Neurol 92:184-194, Fischer, U.,et al, 2022
Thrombectomy versus Medical Management in Mild Strokes due to Large Vessel Occlusion: Exploratory Analysis from the EXTEND-IA Trials and a Pooled International Cohort
Ann Neurol 92:364-378, Sarraj, A.,et al, 2022
Intravenous Thrombolysis with Tenecteplase for the Treatment of Acute Ischemic Stroke
Ann Neurol 92:349-357, Tsivgoulis, G.,et al, 2022
Intravenous Thrombolysis Before Endovascular Thrombectomy for Acute Ischemic Stroke
JAMA 325:229-231, Saver, J.L. & Adeoya, O., 2021
Reperfusion Treatment and Stroke Outcomes in Hospitals with Telestroke Capacity
JAMA Neurol 78:527-535, Wilcock, A.D.,et al, 2021